Hunting vigorously through the lazylaces archives for "point'n'click" unearthed the following results...
Duan is a beautiful point'n'click adventure game project, with some lush graphics and sweet music (read more about the project aspect of the game here), and is available to play in English or German. If I were to try to say what the game is like I'd say "Ninjai meets Samorost" just about covers it, and should explain why I recommend giving it a go as soon as possible [subbed by Nefretit & winniethepooh].
Vanilla Ninja: Dangerzone, and consequently I haven't finished it yet, I can't tell you what the point of the game is, other than to get Vanilla Ninja's, who seem to be an all girl German rock band, song, "Dangerzone", firmly embedded in your head. I'm currently going on the theory that you are trying to point'n'click at least one of the girls up to the top floor of the casino to open the safe. I haven't yet worked out if the order in which you do things is important, if it is I suspect I may need to restart the game as I seem to be stuck with one girl in the kitchen [subbed by winniethepooh]. Update: Did it! You do have to get the girls to the safe, and as far as I can tell you can't do the tasks in the wrong order, so there should be no need to restart at any point.
Delilah & Julius: Global Assignment is a large point'n'click game where you play either Delilah or Julius (you get to choose), who seem to be some kind of special agents. Your task is to trail the bad guys around the globe and thwart their evil bad guy type plans, which is all good fun, especially combined with some nice graphics and sounds (not to mention the groovy intro music), even if the user interface (imho) seems a bit buggy [subbed by sassylassie & winniethepooh].
Atrocitys is a short, but not at all sweet, point'n'click horror thing (there's not really enough here to call it a game), and this is not one for the kids to "play". For the rest of you don't be afraid it will all be over (very) soon [subbed by winniethepooh & f00].
Sononamo mixes up the point'n'click genres a little, using a simple graphical style, by requiring you to click the right objects, in the right order, in order to escape the house [subbed by Sophie].
Cathy Cat from the cage on the ceiling (!) of the girly pink room by using point'n'clickery to trash the room and find the 6 coloured gems that fit into the lock on the cat's cage. I'm not sure what language the game is in, but it's still easy to complete without understanding a word. Old hands at point'n'click games can also play the sub-game (of my own invention) of guessing which classic game the sound effects were from originally [subbed by Nick S The Hamster].
point'n'click skills in The Thief 2 to escape the prison. Playable in English, or Russian if you want an additional challenge! Also try the original episode if you haven't already [subbed by eb, anon, Don & Shiny].
Treasure Hunters (a tie-in with some television series on NBC I have never seen) has expired so you cannot win the cash prizes anymore, but the game is still worth playing for the challenge (unless you are totally money driven of course). The game is a curious mix of point'n'click (with some nice graphics and sound), and puzzles (involving some web searching), and really works quite well. The idea of course is to find the treasure, but you'll have to satisfy yourself with the virtual, rather than real, kind. Note registration is required if that puts you off playing a game, but it seems harmless from my experience [subbed by eljordo & gordon].
point'n'click games people. At first they were happy with trapping us in a room and making it tricky to escape. But increasingly these days they are putting ten locks on the thing so that requires us finding 10 keys. Latest in line in this genre is Escape 3 which is damn tricky. Can you find all the keys and escape the basement? Can you even start? [subbed by Britchick, Helen, Kelly, Matt, Misty, winniethepooh & Mara].
The Legacy Of Pliskin returns, with some nicer graphics, in the logically titled point'n'click sequel The Legacy Of Pliskin 2. My only top tip is totally unrelated to completing the game - leave the game for a while to make him play with his PSP. Weird [subbed by winniethepooh, sopdox, Nefretit, Lost Enigma & Kara].
Grow Nano V1 replaces the speed clicking action of Grow Nano V0 with a hunt'n'click style to test out your point'n'click skills. Play all the way to the end to get an animated reward [subbed by Videocrazy, Tracey & crazy_nuts_2006].
Grow Series continues with a fun little diversion Grow Nano V0. It's more of a speed clicking contest than a point'n'click game, but I'm sure my shiny new laser mouse is more than up to the job [subbed by Lost Enigma].