Hunting vigorously through the lazylaces archives for "point'n'click" unearthed the following results...
Hopping Ham returns for some Halloween based point'n'click adventures in Hopping Ham's Halloween [subbed by camecha].
Master Of Hobby you are trapped in a very messy bedroom, where the objects you find include a handheld computer game console and a box of tissues. Which is why I'd call this point'n'click game, "escape the teenage boy's bedroom" (you know what I'm saying), rather than "Master Of Hobby", which is a translation of the original Japanese title [subbed by Helanren, Nefretit, Meeker, MsInterpret & winniethepooh].
Enigma In The Yellow Rooms, despite it being a rather good point'n'click game, influenced by MOTAS, as there have been a few issues with availability. First the bandwidth on the original site was exceeded, and over the last few days I just couldn't get the flash file to load, but now the 7th room has been added it all seems to be working fine again. The game is like a chain of room escaping games, the idea being you escape one room to get into the next, yellow-themed, room. Currently there are seven to complete, but rooms are still being added. You can keep up with the additions, and other game news, at the official EitYR homepage [subbed by CurryFrank, Kelly, Nefretit, Ree, winniethepooh, Meeker, MsInterpret, BlackKitten, Stella John, JhInG & manon].
The Roomz. There is a little bit of point'n'click, but you'll mainly need your puzzle brain to find the passwords to get from room to room [subbed by MsInterpret, winniethepooh, manon, Meeker, kelly, JhInG, Gerri, Big Russ & czGeorge].
once or twice before if you play a lot of point'n'click games (will you never learn?), hence it's necessary to insert "GH" into the title of The (GH) Museum, so that you know exactly which museum you're escaping this time (it's Games Handbook's, hence the "GH"). In this one you have to fix a variety things in the museum that a group of pesky kids has messed up (ooo - scooby doo moment) before you can escape [subbed by Matt, winniethepooh, MsInterpret, Meeker, neabob, Nefretit, JhInG & Gerri].
8 Days the new "live action" point'n'click game from Anode Et Cathode has been released (the first part at least). If you haven't already, I suggest you sign-up asap and get involved [subbed by Nemrac, Mercy, sassymom08, Helanren, Rachel, Boo, MsInterpret, Debs, sopdox, Richard C, drunkinhamster, freako1120, Faith T, Sean T, crimsonqueen3750, Anster & fatrnu].
Mechenosets is a short and simple point'n'click room escaper. Once you escape the room you can watch a clip from the Russian film that the game is promoting - although I don't recommend this last bit for the kids [subbed by JhInG & Meeker].
point'n'click insanity from Renegade in Bomb. When I say insanity I don't mean the game, although it's not hard to argue it's a little unbalanced, but I mean you, once you've been to point'n'click hell and back trying to solve it. Enjoy [subbed by Heather, Gerri, Ree, Helanren & winniethepooh]
Les Quetes de Sagwa is "The Great Canadian Point'n'Click Cat Mystery", which I think is a little more helpful. In the game you play a cat (who I think might be called Sagwa) and you have to search for a variety of objects. That's as far as I've got so far, and I don't know enough French to understand any more yet [subbed by MsInterpret].
Piep (at Amo-Design) looks like a very simple escape the room point'n'click game, but once you start playing it seems a lot trickier than first appearances might have led you to believe. It's certainly left me in the dark (literally as I seem have blown the fuse) [subbed by Nicop, kelly & winniethepooh].
The Big Escape is a cute point'n'click game for kids, in which you must find the hidden words and then use them correctly in a journal so that you can escape the room [subbed by winniethepooh]. Update: Oh, I just realised the clues change position each time you play - nice.
Futurama: Titanic Game is an easy, if somewhat buggy, point'n'click game of three levels. Level two is the best of the bunch for my money, but even that isn't a great challenge, I do like Futurama though so I was always going to be a sucker for this game [subbed by JhInG].