Hunting vigorously through the lazylaces archives for "point'n'click" unearthed the following results...
Escape Logic involves you solving logic puzzles to escape the room. Of course what would be more logical would be to stop getting trapped in these rooms all the time. But that would be no fun [subbed by f00].
point'n'click cooking to do in Esklavos C7. Pass me the balsamic vinegar... [subbed by Mantari, vmklover, She-Nomad & higgo]. NOTE: When I tried playing this it took a few attempts to get it to load due to the large number of people trying to play. Persist if you don't get it to load first time, it's worth it.
point'n'click it would be awesome (also it would be very time consuming trying to leave any room that you were in). Anyway while the boffins work on that one we can play SSSG: Sneaky Land 4: Incidia instead [subbed by Self Defiant, She-Nomad, Robi, Jumisa, Big Bad Dave & anon].
Magenta Green Room (there seem's to be some confusion over the name, but unless I've gone colour blind it's green) is an escape the room style point'n'click game. The room is Green. You must escape it. You do that by pointing. And clicking. You know sometimes these game descriptions pretty much just write themselves...*takes well deserved break* [subbed by Werewolf].
UPDATE: OK, I don't know what was going on at newgrounds. The game I linked was the green room, the page title said magenta, confusing enough, but then they swapped it back to the magenta room game to match the title. Anyways, I've updated the link now so it goes to the right place.
Gymnasium Escape is a Japanese point'n'click game that looks great, but unfortunately has quite a large language barrier that makes playing it a little tricky. All I've managed to work out so far is how to turn on the power in the storeroom, and I was quite impressed with that. Perhaps between us we can work out what is going on here... [subbed by f00].
Shut.In" (featuring new escape the room games every day) has started it's own series of exclusive point'n'click games called "Locked In" (in which, unsurprisingly, you have to... wait for it... wait for it... escape the room... ahhhh...). I'm assuming this first episode was built by the same people who did the puzzled series as it's very similar to, but not entirely the same as, Puzzled 4 [subbed by Mystery].
Voice: another day, another totally totally incomprehensible Japanese point'n'click game in which I assume I'm aiming to escape the room... One day, I swear to you, these things are going to teach me Japanese. Although, that would have to be after the day that I get round to installing the right character sets/fonts so that the text displays properly... [subbed by Mantari & handyrman].
Cauchemars Series of point'n'click games for kids has resurfaced as "Nightmares", the main difference being that these are English translations of the original French games ("Cauchemars" is French for "Nightmares" translation fans). Anyway, you can play the English episodes here: handyrman & SonicLover].
Face Room is a Japanese escape the room game featuring cute little square faces... obviously [subbed by Mystery & Catraven].
Legend Room is a promotional Japanese point'n'click game (apparently by the gotmail team) with a nice twist - the action is in video "live" action, which really gives the thing a very nice visual look. Unfortunately that also means the load times are rather long, but it's worth the wait [subbed by Mystery, Werewolf & im4noles2].