Sphere Core. Not so strange is the goal: escape the room. That part is as familiar as an old comfy sweater [subbed by handyrman, karstenmp, PnCAddict, Mystery & anon].
JPRS24 Escape is an escape the room game with some fine graphics (I believe the team behind it are connected to gotmail, and point'n'click aficionados will spot the similarities straight away) that initially seems hard to understand (it's in Japanese). But once you get passed the intro screens, which I found totally incomprehensible (the skip button is your friend), things get more familiar and playable [subbed by Mystery & Mantari].
Escape From Younger Sister's Room is somewhat obvious from the game's title, it's just achieving that goal that is a little tricky. All that my point'n'click efforts so far have managed to reveal are a million and one scraps of paper with indecipherable Japanese text on them [subbed by Abby & winniethepooh].
Hidden C1: Esencia Primitiva , the English Version, "Hidden C1 - Primitive Essence", is now available to play. It's still not suitable for kids though [subbed by Mantari].
Cauchemars Series of point'n'click games recently made a reappearance in English as "Nightmares", and now Cauchemars Episode 5 has been released, super cute as ever, but only in the original French format. It shouldn't stop you playing, and enjoying, the game, but drop me a line all the same should you spot an English release anywhere [subbed by Mantari & winniethepooh].
Yu A's Room [subbed by Mystery & handyrman].
Yuria's Room 3 is quite a tricky little escape the room proposition, at least it is for those of that don't understand Japanese [subbed by winniethepooh, Catraven & roko].
Nazono Heya Room might be slightly baffling as it's in Japanese, but the locked door, waste-paper basket and computer on the desk should all be familiar to seasoned point'n'clickers [subbed by Tia].
Prawn To Be Wild 3 sees the little prawn fella returning in a point'n'click slidey puzzle thing in which you must "escape the shopping bag" (allowing us to cross off another "escape the..." locale from our list). Once again it's not entirely suitable for children [subbed by Krumpet, vgaforums.com, handyrman, SmashMan140 & salocius].
Industrial Zombie Grow is one of those point'n'click games where you have to select things in the right sequence in order to win - a genre made famous by the Grow Series which apparently this game was made in tribute to [subbed by Jania].
El Legado is a creeptacular point'n'click adventure game. If the atmospheric sound effects and dark graphics don't spook you, then playing hunt-the-pixel in Spanish will. Fortunately the [TAB] key is your friend in this game, and hopefully some kind soul will give us some translations in the comments. You start by trying to escape the cell, then there is more for you to explore from there [subbed by Mystery].