Hunting vigorously through the lazylaces archives for "point'n'click" unearthed the following results...
K-Sensor has put me into a hypnotic trance which has made me insist that you play. You must obey [subbed by VictoriaV, Mystery & EscapeGirl].
The Night Before is the prequel to The Morning After which makes all kinds of logical sense to me. Anyway... The game contains several mini games and lots of "adult themes", which means it's definitely not one for the kids, you probably shouldn't play it at work, and those of you that are easily offended should almost certainly skip it too. The rest of you feel free to giggle immaturely whilst you play though [subbed by VictoriaV & Psionic].
Eskkapee might be just a short escape the room game, but it manages to include a test of just how speedily you can point'n'click as you try to reach your usual freedom goal. So it's time to limber up those fingers, and to draw upon that wealth of experience you've built up. On your marks, get set, click [subbed by eskkapo & VictoriaV].
Escape Day is certainly a cute looking game, I'm having a bit of an issue with the language though [subbed by VictoriaV].
Meat Mansion as you try to escape the mansion using your point'n'click skills, in between shooting rampaging un-dead zombies as they try to scoop out your delicious living brain. In many ways this game could be considered not suitable for children, just in case you're missing my subtle sub-text here [subbed by Buji & Smashman140].
Escape Artist [subbed by Buji, RookieRiddler & lesley].
Escape02 - Who Am I? is a Japanese escape the room game, handily translated into English for us non Japanese speakers, with some sweet graphics and theme music [subbed by Mantari, Buji & Mystery].
The Ballad of Ketinetto would be at number one, narrowly beating The Ballad Of Cornetto into second place [subbed by VictoriaV, Buji, Mystery & theidiotcircusboy].
Pegasus Room Escape. Because the real, non-mythical, creatures, have run out... dragon's being quite common these days before you say anything [subbed by Mystery].
Shimaka Raderu seems obvious. You've parachuted onto a forested island, and now you are trying to escape. Great stuff. And the graphics and sound effects are nice too. There are some odd bits though. That bit with the snake and crocodile for instance. If anyone could tell me what was going with that I'd love to know [subbed by Buji & Mystery].
Totem Destroyer is an arcade, puzzle, strategy, point'n'click, reverse-Jenga, style game in which you must knock stuff over, but in a careful, subtle, not too destructive fashion. It is addictive. You have been warned [subbed by DaSozz].